Muscle sympathetic reactivity to apneic and exercise stress in high-altitude Sherpa
نویسندگان
چکیده
منابع مشابه
Metabolic basis to Sherpa altitude adaptation.
The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen delivery in comparison to Lowlander populations have been postulated to play a role in such adaptation. Whether differences in tissue oxygen utilization (i.e., metabolic adaptation) underpin this adaptation is not known, ...
متن کاملHigh altitude and oxidative stress.
Exposure to high altitude, which is associated with decreased oxygen pressure, could result in oxidative/reductive stress, enhanced generation of reactive oxygen and nitrogen species (RONS), and related oxidative damage to lipids, proteins, and DNA. The severity of oxidative challenge is related to the degree of altitude. A wide range of RONS generating systems are activated during exposure to ...
متن کاملKing of the mountains: Tibetan and Sherpa physiological adaptations for life at high altitude.
Anecdotal evidence surrounding Tibetans' and Sherpas' exceptional tolerance to hypobaric hypoxia has been recorded since the beginning of high-altitude exploration. These populations have successfully lived and reproduced at high altitude for hundreds of generations with hypoxia as a constant evolutionary pressure. Consequently, they are likely to have undergone natural selection toward a genot...
متن کاملSympathetic Vasoconstriction in Skeletal Muscle: Adaptations to Exercise Training.
JUST, T.P., I.R. COOPER, and D.S. DELOREY. Sympathetic vasoconstriction in skeletal muscle: adaptations to exercise training. Exerc. Sport Sci. Rev., Vol. 44, No. 4, pp. 137–143, 2016. Sympathetic vasoconstriction in the skeletal muscle vascular bed is essential for the regulation of vascular resistance and therefore control of blood pressure and muscle blood flow at rest and during exercise. I...
متن کاملAugmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema.
BACKGROUND Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. Cardiovascular adjustments to hypoxia are mediated, at least in part, by the sympathetic nervous system, and sympathetic activation promotes pulmonary vasoconstriction and alveolar fluid flooding in experimental animals. METHODS AND RESULTS We measured sympathetic nerve act...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2020
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00119.2019